Hello Bio/Torcetrapib/HB0879/10mg
市场价：
¥2691.00
美元价：
2070.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameTorcetrapib
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Short descriptionCholesteryl ester transfer protein inhibitor
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Biological descriptionCholesteryl ester transfer protein (CETP) inhibitor. Raises HDL in dyslipidemia, improves glucose homeostasis and insulin resistance. Inhibits vasodilation and increases aldosterone to show hypertensive actions.
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Biological actionInhibitor
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Purity>99%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name(2R,4S)-4-[[[3,5-bis(Trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-6- (trifluoromethyl)-1,2,3,4-tetrahydroquinoline-1-carboxylic acid ethyl ester
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Molecular Weight600.47
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Chemical structure
![Torcetrapib [262352-17-0]](images/hellobio/201710/hb0879.png "Torcetrapib [262352-17-0]")
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Molecular FormulaC26H25F9N2O4
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CAS Number262352-17-0
Storing and Using Your Product
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Storage instructionsroom temperature
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Solubility overviewsoluble in DMSO (50mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Torcetrapib
Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition.
Connelly MA et al (2010) J Cardiovasc Pharmacol 55(5) : 459-68.PubMedID: 20051879Raising HDL with CETP inhibitor torcetrapib improves glucose homeostasis in dyslipidemic and insulin resistant hamsters.
Briand F et al (2014) Atherosclerosis 233(2) : 359-62.PubMedID: 24530763Upregulating reverse cholesterol transport with cholesteryl ester transfer protein inhibition requires combination with the LDL-lowering drug berberine in dyslipidemic hamsters.
Briand F et al (2013) Arterioscler Thromb Vasc Biol 33(1) : 13-23.PubMedID: 23139291
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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