Hello Bio/Topiramate/HB0618/
市场价：
¥1989.00
美元价：
1530.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameTopiramate
- ShortdescriptionSelectiveGluK1kainatereceptorantagoNIST
- BIOLOGicaldescriptionSelectiveGluK1kainatereceptorantagonist(IC50=0.46µM).Also,positiveallostericGABAAreceptormodulatorandinhibitscarbonicanhydrase(KivaluesforratcarbonicanhydraseIIandIVare0.1-1and0.2µMrespectively).InhibitsL-typeCa2+andNavchannels(IC50=48.9µM).Showsanticonvulsantactivity.
- BiologicalactionAntagonist
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranosesulfamate
- MolecularWeight339.36
- Chemicalstructure
![Topiramate [97240-79-4]](images/hellobio/201710/hb0618.png "Topiramate [97240-79-4]")
- MolecularFormulaC12H21NO8S
- CASNumber97240-79-4
- PubChemidentifier5284627
- SMILESCC1(O[C@@H]2CO[C@@]3([C@H]([C@@H]2O1)OC(O3)(C)C)COS(=O)(=O)N)C
- InChiInChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
- InChiKeyKJADKKWYZYXHBB-XBWDGYHZSA-N
- MDLnumberMFCD00865320
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewSolubleinDMSO(100mM)andinethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforTopiramate
Topiramateattenuatesvoltage-gatedsodiumcurrentsinratcerebellargranulecells.
ZonaCetal(1997)NeurosciLett231(3):123-6.PubMedID:9300637Topiramateasaninhibitorofcarbonicanhydraseisoenzymes.
DodgsonSJetal(2000)Epilepsia41Suppl1:S35-9.PubMedID:10768298SelectiveantagonismofGluR5kainate-receptor-mediatedsynapticcurrentsbytopiramateinratbasolateralamygdalaneurons.
GryderDSetal(2003)JNeurosci23(18):7069-74.PubMedID:12904467Topiramatemodulationofβ(1)-andβ(3)-homomericGABA(A)receptors.
SimeoneTAetal(2011)PharmacolRes64(1):44-52.PubMedID:21421049
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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