Hello Bio/Tiagabine hydrochloride/HB0978/50mg
市场价：
¥3159.00
美元价：
2430.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameTiagABInehydrochloride
- ShortdescriptionSelectiveGAT-1GABAuptakeinhibitor
- BIOLOGicaldescriptionSelectiveGAT-1GABAuptakeinhibitor(IC50=67nM).SelectiveforGAT-1overmGAT2,mGAT3andmGAT4(IC50valuesare0.8,300,>300and800µMrespectively).Showsanticonvulsive,antinociceptive,anxiolyticandantidepressantactions.Blood-brainbarrierpermeable.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(3R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylicacidhydrochloride
- MolecularWeight412.01
- Chemicalstructure
![Tiagabine hydrochloride [145821-59-6]](images/hellobio/201710/hb0978.png "Tiagabine hydrochloride [145821-59-6]")
- MolecularFormulaC20H25NO2S2.HCl
- CASNumber145821-59-6
- PubChemidentifier91274
- SMILESCC1=C(SC=C1)C(=CCCN2CCC[C@H](C2)C(=O)O)C3=C(C=CS3)C.Cl
- InChiInChI=1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1
- InChiKeyYUKARLAABCGMCN-PKLMIRHRSA-N
- MDLnumberMFCD07369025
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature(desiccate)
- SolubilityoverviewSolubleinwater(50mM)andinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforTiagabinehydrochloride
Long-termanxiolyticandantidepressant-likebehaviouraleffectsoftiagabine,aselectiveGABAtransporter-1(GAT-1)inhibitor,coincidewithadecreaseinHPAsystemactivityinC57BL/6mice.
ThoeringerCKetal(2010)JPsychopharmacol24(5):733-43.PubMedID:19346277Correlationbetweenanticonvulsantactivityandinhibitoryactiononglialgamma-aminobutyricaciduptakeofthehighlyselectivemousegamma-aminobutyricacidtransporter1inhibitor3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazoleanditsN-alkyla
WhiteHSetal(2002)JPharmacolExpTher302(2):636-44.PubMedID:12130726Comparisonofantiepilepticdrugstiagabine,lamotrigine,andgabapentininmousemodelsofacute,prolonged,andchronicnociception.
LaughlinTMetal(2002)JPharmacolExpTher302(3):1168-75.PubMedID:12183677
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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