Hello Bio/Tiagabine hydrochloride/HB0978/10mg
市场价：
¥799.50
美元价：
615.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameTiagabine hydrochloride
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Short descriptionSelective GAT-1 GABA uptake inhibitor
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Biological descriptionSelective GAT-1 GABA uptake inhibitor (IC50 = 67 nM). Selective for GAT-1 over mGAT2, mGAT3 and mGAT4 (IC50 values are 0.8, 300, >300 and 800 µM respectively). Shows anticonvulsive, antinociceptive, anxiolytic and antidepressant actions. Blood-brain barrier permeable.
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Biological actionInhibitor
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Purity>99%
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Properties
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Chemical name(3R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid hydrochloride
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Molecular Weight412.01
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Chemical structure
![Tiagabine hydrochloride [145821-59-6]](images/hellobio/201710/hb0978.png "Tiagabine hydrochloride [145821-59-6]")
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Molecular FormulaC20H25NO2S2.HCl
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CAS Number145821-59-6
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PubChem identifier91274
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SMILESCC1=C(SC=C1)C(=CCCN2CCC[C@H](C2)C(=O)O)C3=C(C=CS3)C.Cl
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InChiInChI=1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1
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InChiKeyYUKARLAABCGMCN-PKLMIRHRSA-N
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MDL numberMFCD07369025
Storing and Using Your Product
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Storage instructionsRoom temperature (desiccate)
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Solubility overviewSoluble in water (50mM) and in DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Tiagabine hydrochloride
Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice.
Thoeringer CK et al (2010) J Psychopharmacol 24(5) : 733-43.PubMedID: 19346277Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkyla
White HS et al (2002) J Pharmacol Exp Ther 302(2) : 636-44.PubMedID: 12130726Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception.
Laughlin TM et al (2002) J Pharmacol Exp Ther 302(3) : 1168-75.PubMedID: 12183677
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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