Hello Bio/Thapsigargin/HB1118/
市场价：
¥1735.50
美元价：
1335.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameThapsigargin
- ShortdescriptionPotent,non-competitiveSERCAinhibitor
- BIOLOGicaldescriptionPotentandnon-competitivesarco-endoplasmicCa2+-ATPase(SERCA)inhibitor.Activatesendoplasmicreticulumstressmechanisms.Inducesapoptosisinmostcells.Showsanticancerandneuroprotectiveactions.
- BiologicalactionInhibitor
- Purity>97%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yloctanoate
- MolecularWeight650.76
- Chemicalstructure
![Thapsigargin [67526-95-8]](images/hellobio/201710/hb1118.png "Thapsigargin [67526-95-8]")
- MolecularFormulaC34H50O12
- CASNumber67526-95-8
- PubChemidentifier446378
- SMILESCCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=CC)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O
- InChiInChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
- InChiKeyIXFPJGBNCFXKPI-FSIHEZPISA-N
- MDLnumberMFCD00083511
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewSolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforThapsigargin
Endoplasmicreticulumstressinducedbytunicamycinandthapsigarginprotectsagainsttransientischemicbraininjury:InvolvementofPARK2-dependentmitophagy.
ZhangXetal(2014)Autophagy10(10):1801-13.PubMedID:25126734Targetingthapsigargintowardstumors.
DoanNTetal(2014)Steroids:PubMedID:25065587Targetingthapsigargintowardstumors.
DoanNTetal(2014)Steroids:PubMedID:25065587
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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