你好Bio/柠檬酸河豚毒素/HB1035/1mg-免疫在线蚂蚁淘旗下平台

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商品详细你好Bio/柠檬酸河豚毒素/HB1035/1mg

你好Bio/柠檬酸河豚毒素/HB1035/1mg

商品编号： HB1035

品牌： hellobio

市场价： ¥2320.50

美元价： 1785.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Productoverview

Name
Tetrodotoxincitrate
Shortdescription
Potent,selective,use-dependentNa⁺channelblocker.CitrateSalt.
BIOLOGicaldescription
Potent,selectiveandreversIBLe,voltagedependentNa⁺channelblocker.Usedependent.CitrateSalt.CommonlyusedinelectrophysiologicalpreparationstoblockorreduceexcitABIlity.
Alternativenames
TTX;TTXcitrate
Biologicalaction
Blocker
Purity
>99%
Specialrequirements
Asthisproductisatoxin,customersarerequiredtocompleteashortenduserdeclarationwhenordering.Ourcustomercareteamwillbehappytohelpyouwiththis.
Customercomments
Tetrodotoxincitrate fromHelloBioworkedperfectlyasexpectedandblockedactionpotentialfiringatconcentrationsof100nMandabove.IwouldrecommendtheuseofTetrodotoxincitratefromHelloBioforuseinelectrophysiologyrecordings.MattUdakis,PhDstudent,UniversityofBath,UK
HelloBioproduceveryhighqualityTTXcitrate,whichfullyblocksNaVchannelsandprovidesgoodvalueformoney.Verifiedcustomer,TheUniversityofEdinburgh
JustwashedtheTetrodotoxincitrate(TTX)onanditworksasexpected(itinhibitsthefibrevolleyat1μM).Verifiedcustomer,TheUniversityofBristol
Ourproductsinaction
2citationsSubmitYourCitationNow

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Properties

Chemicalname
Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentolcitrate
MolecularWeight
319.27
Chemicalstructure
MolecularFormula
C₁₁H₁₇N₃O₈
CASNumber
18660-81-6
PubChemidentifier
54592378
SMILES
C(C(=O)O)C(CC(=O)O)(C(=O)O)O.C([C@@]1([C@@H]2[C@@H]3[C@H](N=C(N[C@]34[C@@H]([C@H]1O[C@]([C@H]4O)(O2)O)O)N)O)O)O
Source
Extractedfromfugu
InChi
InChI=1S/C11H17N3O8.C6H8O7/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-7,15-20H,1H2,(H3,12,13,14);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t2-,3-,4+,5-,6-,7+,9+,10+,11+;/m1./s1
InChiKey
YUJWMDOXROTQCW-WNGAXIQVSA-N
Appearance
Whitesolid

Applications

Applicationnotes
Tetrodotoxiniscommonlyusedinelectrophysiologytoblockexcitabilitybyinhibitingactionpotentialfiringwithinneurons.Itiscommonlyappliedatconcentrationsof1μM.TetrodotoxinfromHelloBioworksasexpectedandblocksactionpotentialfiringatconcentrationsof100nMandabove(seeFig1and2above).

#Protocol1:EffectofTTXcitrateonactionpotentialsinmousecorticalneurons
- WholecellvoltageclamprecordingswereobtainedfromlayerVpyramidalneuronsofthemouseprelimbiccortexbrainslice.
- Neuronswereheldattherestingmembranepotential(~-70mV)andinjectedwitha500pA300mscurrentsteptoinduceactionpotentialfiring.
- TTXwasbathappliedfor10minfirstat100nMthen300nM,1μMand2μM.Aftereachdrugapplicationacurrentstepwasrecordedtoassessactionpotentialblockade.
#Protocol2:EffectofTTXcitrateonEPSPsandactionpotentialfiringinmousecorticalneurons
- WholecellvoltageclamprecordingswereobtainedfromlayerVpyramidalneuronsofthemouseprelimbiccortexbrainslice.
- Neuronswereheldattherestingmembranepotential(~-70mV)andEPSPwereevokedbyplacingastimulatingelectrodeclosetotherecordedtheneuroninlayerII/III.
- EPSPsandactionpotentialswereevokedbysinglesquare(150μs)pulseevery10secwithanintensitythatproducedbothanEPSPandactionpotential.
- TTXwasbathappliedfor10minfirstat100nMthen300nM,1μMand2μMwhistcontinuallyevokingandrecordingEPSP/A.Ps.

StoringandUsingYourProduct

Storageinstructions
-20°C(desiccate)
Solubilityoverview
Solubleinwater(1mg/ml)
Important
ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforTetrodotoxincitrate

Theprotectiveactionoftetrodotoxinand(+/-)-kavainonanaerobicglycolysis,ATPcontentandintracellularNa+andCa2+ofanoxicbrainvesicles.
GleitzJetal(1996)Neuropharmacology35(12):1743-52.
PubMedID:9076753
AntagoNISTiceffectsoftetrodotoxinonaconitine-inducedcardiactoxicity.
OnoTetal(2013)JNipponMedSch80(5):350-61.
PubMedID:24189353
Tetrodotoxin:chemistry,toxicity,source,distributionanddetection.
BaneVetal(2014)Toxins(Basel)6(2):693-755.
PubMedID:24566728
Tetrodotoxinformoderatetoseverecancerpain:arandomized,doubleblind,paralleldesignmulticenterstudy.
HagenNAetal(2008)JPainSymptomManage35(4):420-9.
PubMedID:18243639

品牌介绍

Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.

公司介绍

品牌分类

拮抗剂和抑制剂抗生素激动剂和活化剂初级的染料和污渍

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