Hello Bio/TCN 201/HB0604/10mg
市场价：
¥2574.00
美元价：
1980.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameTCN 201
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Short descriptionPotent, non-competitive GluN2A subunit selective NMDA receptor antagonist
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Biological descriptionPotent and non-competitive GluN2A subunit selective NMDA receptor antagonist (pIC50 values are 6.8 and <4.3 for="" glun2a="" and="" glun2b="" respectively="" in="" a="">2+ assay). Binds at allosteric site. Inhibition is GluN1 co-agonist (glycine or D-serine) concentration dependent. Shows anti-nicotine addiction effects.
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Biological actionAntagonist
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Purity>99%
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Our products in action1 citation Submit Your Citation Now
Images
Properties
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Chemical name3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
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Molecular Weight461.89
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Chemical structure
![TCN 201 [852918-02-6]](images/hellobio/201710/hb0604.png "TCN 201 [852918-02-6]")
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Molecular FormulaC21H17ClFN3O4S
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CAS Number852918-02-6
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PubChem identifier4787937
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SMILESC1=CC=C(C=C1)C(=O)NNC(=O)C2=CC=C(C=C2)CNS(=O)(=O)C3=CC(=C(C=C3)F)Cl
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InChiInChI=1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
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InChiKeyFYIBXBFDXNPBSF-UHFFFAOYSA-N
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MDL numberMFCD06683895
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewSoluble in DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for TCN 201
TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.
Edman S et al (2012) Neuropharmacology 63(3) : 441-9.PubMedID: 22579927Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.
Hansen KB et al (2012) J Neurosci 32(18) : 6197-208.PubMedID: 22553026Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.
Bettini E et al (2010) J Pharmacol Exp Ther 335(3) : 636-44.PubMedID: 20810618Reinstatement of nicotine seeking is mediated by glutamatergic plasticity.
Gipson CD et al (2013) Proc Natl Acad Sci U S A 110(22) : 9124-9.PubMedID: 23671067
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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