Hello Bio/DL-TBOA/HB0258/50mg
市场价：
¥8989.50
美元价：
6915.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameDL-TBOA
- ShortdescriptionCompetitiveEAATblocker.Inhibitsglutamateuptake.
- BIOLOGicaldescriptionCompetitive,non-transportableEAATblocker(IC50valuesare70,6and6µMforEAAT1,EAAT2andEAAT3respectivelyandKivaluesare4.4and3.2µMforEAAT4andEAAT5.SelectiveforEAAtransportersoverionotropicandmetabotropicglutamatereceptors.Inhibitsglutamateuptake.
- BiologicalactionBlocker
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameDL-threo-β-Benzyloxyasparticacid
- MolecularWeight239.23
- Chemicalstructure
![DL-TBOA [205309-81-5]](images/hellobio/201710/hb0258.png "DL-TBOA [205309-81-5]")
- MolecularFormulaC11H13NO5
- CASNumber205309-81-5
- PubChemidentifier5311218
- SMILESC1=CC=C(C=C1)CO[C@@H]([C@@H](C(=O)O)N)C(=O)O
- SourceSynthetic
- InChi1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1
- InChiKeyBYOBCYXURWDEDS-IUCAKERBSA-N
- AppearanceOff-whitesolid
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewSolubleinDMSO(100mM,gentlewarming)orwater(5mM,gentlewarming)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforDL-TBOA
Synthesesofopticallypurebeta-hydroxyaspartatederivativesasglutamatetransporterblockers.
ShimamotoKetal(2000)BioorgMedChemLett10(21):2407-10.PubMedID:11078189DL-threo-beta-benzyloxyaspartate,apotentblockerofexcitatoryaminoacidtransporters.
ShimamotoKetal(1998)MolPharmacol53(2):195-201.PubMedID:9463476NeurotoxicandneuroprotectiveeffectsoftheglutamatetransporterinhibitorDL-threo-beta-benzyloxyaspartate(DL-TBOA)duringphysiologicalandischemia-likeconditions.
BondeCetal(2003)NeuRochemInt43(4-5):371-80.PubMedID:12742081
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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