Hello Bio/Tamoxifen Citrate/HB0602/5g
市场价：
¥6591.00
美元价：
5070.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameTamoxifen Citrate
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Short descriptionEstrogen receptor antagonist/ partial agonist
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Biological descriptionEstrogen receptor antagonist and also partial agonist. Also potent chloride channel HSV-1 inhibitor. Blood brain barrier permeable. Inhibits tumor growth and induces apoptosis in breast cancer cells. Selectively inhibits sterol biosynthesis (IC50 = 1000 nM). Shows neuroprotective potential.
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Biological actionAntagonist
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Purity>99%
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Properties
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Molecular Weight563.7
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Chemical structure
![Tamoxifen Citrate [54965-24-1]](images/hellobio/201710/hb0602.png "Tamoxifen Citrate [54965-24-1]")
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Molecular FormulaC32H37NO8
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CAS Number54965-24-1
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PubChem identifier2733525
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SMILESCCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewsoluble in Dimethylsulfoxide (100mM), methanol (50mg/ml, gentle warming) or ethanol (10mg/ml, sonication)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Tamoxifen Citrate
Tamoxifen inhibits inward rectifier K+ 2.x family of inward rectifier channels by interfering with phosphatidylinositol 4,5-bisphosphate-channel interactions.
Ponce-Balbuena D et al (2009) J Pharmacol Exp Ther 331(2) : 563-73.PubMedID: 19654266Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase.
Paul R et al (1998) J Pharmacol Exp Ther 285(3) : 1296-302.PubMedID: 9618436Growth inhibition of estrogen receptor-positive and aromatase-positive human breast cancer cells in monolayer and spheroid cultures by letrozole, anastrozole, and tamoxifen.
Kijima I et al (2005) J Steroid Biochem Mol Biol 97(4) : 360-8.PubMedID: 16263272Inhibition of herpes simplex virus type 1 entry by chloride channel inhibitors tamoxifen and NPPB.
Zheng K et al (2014) Biochem Biophys Res Commun 446(4) : 990-6.PubMedID: 24657267
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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