Hello Bio/TAK 715/HB0599/50mg
市场价：
¥11388.00
美元价：
8760.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameTAK715
- ShortdescriptionPotent,p-38MAPkinaseinhibitor.Wnt/β-cateninsignalinginhibitor.
- BIOLOGicaldescriptionPotentp-38MAPkinaseinhibitor(IC50=7.1nMforp-38MAPKα).AlsoWnt-3a-stimulatedβ-cateninsignallinginhibitor.Showsanti-rheumaticandanti-inflammatoryproperties.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide
- MolecularWeight399.51
- Chemicalstructure
![TAK 715 [303162-79-0]](images/hellobio/201710/hb0599.png "TAK 715 [303162-79-0]")
- MolecularFormulaC24H21N3OS
- CASNumber303162-79-0
- PubChemidentifier9952773
- SMILESCCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)C
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforTAK715
InhibitionofWnt/β-cateninsignalingbyp38MAPkinaseinhibitorsisexplainedbycross-reactivitywithcaseinkinaseIδ/ε.
VerkaarFetal(2011)ChemBiol18(4):485-94.PubMedID:21513885Novelinhibitorofp38MAPkinaseasananti-TNF-alphadrug:discoveryofN-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide(TAK-715)asapotentandorallyactiveanti-rheumatoidarthritisagent.
MiwatashiSetal(2005)JMedChem48(19):5966-79.PubMedID:16162000X-raystructureofp38αboundtoTAK-715:comparisonwiththreeclassicinhibitors.
AzevedoRetal(2012)ActaCrystallogrDBiolCrystallogr68(Pt8):1041-50.PubMedID:22868770
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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