你好Bio/SU 5402/HB3133/1mg
市场价：
¥3159.00
美元价：
2430.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameSU5402
- ShortdescriptionPotentFGFRandVEGFRinhibitor.Attenuatesintegrinβ4-inducedneuralstemcelldifferentiation.
- BIOLOGicaldescriptionPotentFGFRandVEGFRinhibitor(IC50valuesare0.02,0.03,0.51and>100µMatVEGFR2,FGFR1,PDGFRβandEGFRrespectively).Attenuatesintegrinβ4-inducedneuralstemcelldifferentiation.Showspotentinvitroandinvivoanticanceractivity.
- BiologicalactionInhibitor
- Purity>95%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoicacid
- MolecularWeight296.32
- Chemicalstructure
![SU 5402 | [215543-92-3]](images/hellobio/201710/hb3133_2.png "SU 5402 | [215543-92-3]")
- MolecularFormulaC17H16N2O3
- CASNumber215543-92-3
- SMILESCc1c[nH]c(c1CCC(=O)O)/C=C2/c3ccccc3NC2=O
- MDLnumberMFCD08235144
- AppearanceLightorangetodarkorange
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforSU5402
Design,synthesis,andevaluationsofsubstituted3-[(3-or4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-onesasinhibitorsofVEGF,FGF,andPDGFreceptortyrosinekinases.
Sunetal(1999)JMedChem42(25):5120-30PubMedID:10602697Neuralstemcelldifferentiationismediatedbyintegrinbeta4invitro.
Suetal(2009)IntJBiochemCellBiol41(4):916-24PubMedID:18834954Rapidandefficientdirecteddifferentiationofhumanpluripotentstemcellsintoretinalpigmentedepithelium.
Buchholzetal(2013)StemCellsTranslMed2(5):384-93PubMedID:23599499
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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