Hello Bio/SP 600125/HB2234/10mg
市场价：
¥1813.50
美元价：
1395.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameSP600125
- ShortdescriptionSelective,ATP-competitiveJNKinhibitor.PreventsBMP9-inducedosteogenicMSCdifferentiation.
- BIOLOGicaldescriptionSelectiveandreversIBLeATP-competitivec-JunN-terminalKinase(JNK)inhibitor(IC50valuesare40-90µMatJNK1,2,3).Showsselectivityoverarangeofotherkinases.Dose-dependentlyinhibitsJNKphosphorylationandinhibitsgeneexpressionofCOX-2,IL-2,IFN-γandTNF-α.PreventsBMP9-inducedosteogenicmesenchymalstemcell(MSC)differentiation.Activeinvivo.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameAnthra[1-9-cd]pyrazol-6(2H)-one
- MolecularWeight220.23
- Chemicalstructure
![SP 600125 [129-56-6]](images/hellobio/201710/hb2234.png "SP 600125 [129-56-6]")
- MolecularFormulaC14H8N2O
- CASNumber129-56-6
- PubChemidentifier8515
- SMILESC1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O
- InChiInChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
- InChiKeyACPOUJIDANTYHO-UHFFFAOYSA-N
- MDLnumberMFCD00022289
- AppearanceYellowsolid
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(5mM,gentlewarming)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforSP600125
SP600125,ananthrapyrazoloneinhibitorofJunN-terminalkinase.
BennettBLetal(2001)ProcNatlAcadSciUSA98(24):13681-6.PubMedID:11717429SP600125,aselectiveJNKinhibitor,protectsischemicrenalinjuryviasuppressingtheextrinsicpathwaysofapoptosis.
WangYetal(2007)LifeSci80(22):2067-75.PubMedID:17459422SP600125,ananthrapyrazoloneinhibitorofJunN-terminalkinase.
BennettBLetal(2001)ProcNatlAcadSciUSA98(24):13681-6.PubMedID:11717429
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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