Hello Bio/SL327/HB1350/50mg
市场价：
¥9126.00
美元价：
7020.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameSL327
- ShortdescriptionSelectiveMEK1andMEK2inhibitor
- BIOLOGicaldescriptionSelectiveMEK1andMEK2inhibitor(IC50valuesare0.18and0.22µMforMEK1andMEK2respectively)whichallowsselectiveinhibitionofERKactivation.Blockslongtermpotentiation(LTP)inhippocampalslicesinratCA1.Alsodisruptslearningandmemoryandexhibitsneuroprotectiveproperties.Bloodbrainbarrierpermeableandactiveinvivo.
- AlternativenamesSL327
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalnameα-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
- MolecularWeight335.35
- Chemicalstructure
![SL327 [305350-87-2]](images/hellobio/201710/hb1350.png "SL327 [305350-87-2]")
- MolecularFormulaC16H12F3N3S
- CASNumber305350-87-2
- PubChemidentifier9549284
- SMILESC1=CC=C(C(=C1)/C(=C(N)/SC2=CC=C(C=C2)N)/C#N)C(F)(F)F
- SourceSynthetic
- InChiInChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
- InChiKeyJLOXTZFYJNCPIS-FYWRMAATSA-N
- MDLnumberMFCD06411432
- AppearanceWhitesolid
StoringandUsingYourProduct
- Storageinstructions+4°C(desiccate)
- SolubilityoverviewSolubleinDMSO(100mM)andinethanol(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforSL327
Regulationofcyclooxygenase-2inductioninthemouseuterusduringdecidualization.Aneventofearlypregnancy.
ScherlePAetal(2000)JBiolChem275(47):37086-92.PubMedID:10969080SignificantneuroprotectionagainstischemicbraininjurybyinhibitionoftheMEK1proteinkinaseinmice:explorationofpotentialmechanismassociatedwithapoptosis.
WangXetal(2003)JPharmacolExpTher304(1):172-8.PubMedID:12490588AnecessityforMAPkinaseactivationinmammalianspatiallearning.
SelcherJCetal(1999)LearnMem6(5):478-90.PubMedID:10541468
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
