Hello Bio/SL327/HB1350/10mg
市场价：
¥2203.50
美元价：
1695.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameSL327
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Short descriptionSelective MEK1 and MEK2 inhibitor
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Biological descriptionSelective MEK1 and MEK2 inhibitor (IC50 values are 0.18 and 0.22 µM for MEK1 and MEK2 respectively) which allows selective inhibition of ERK activation. Blocks long term potentiation (LTP) in hippocampal slices in rat CA1. Also disrupts learning and memory and exhibits neuroprotective properties. Blood brain barrier permeable and active in vivo.
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Alternative namesSL 327
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Biological actionInhibitor
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical nameα-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
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Molecular Weight335.35
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Chemical structure
![SL327 [305350-87-2]](images/hellobio/201710/hb1350.png "SL327 [305350-87-2]")
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Molecular FormulaC16H12F3N3S
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CAS Number305350-87-2
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PubChem identifier9549284
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SMILESC1=CC=C(C(=C1)/C(=C(N)/SC2=CC=C(C=C2)N)/C#N)C(F)(F)F
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SourceSynthetic
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InChiInChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
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InChiKeyJLOXTZFYJNCPIS-FYWRMAATSA-N
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MDL numberMFCD06411432
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AppearanceWhite solid
Storing and Using Your Product
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Storage instructions+4°C (desiccate)
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Solubility overviewSoluble in DMSO (100 mM) and in ethanol (50 mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for SL327
Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy.
Scherle PA et al (2000) J Biol Chem 275(47) : 37086-92.PubMedID: 10969080Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis.
Wang X et al (2003) J Pharmacol Exp Ther 304(1) : 172-8.PubMedID: 12490588A necessity for MAP kinase activation in mammalian spatial learning.
Selcher JC et al (1999) Learn Mem 6(5) : 478-90.PubMedID: 10541468
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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