Hello Bio/SKF 89976A hydrochloride/HB0976/
市场价：
¥1345.50
美元价：
1035.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameSKF89976Ahydrochloride
- ShortdescriptionPotent,selective,competitiveGAT-1GABAuptakeinhibitor
- BIOLOGicaldescriptionPotent,selectiveandcompetitiveGAT-1GABAuptakeinhibitor.SelectiveforGAT-1overGAT-2,GAT-3andBGT-1(IC50valuesare0.13,550,944and7210µMrespectively).InhibitsGABAuptake(Ki=7µM)andtransmitter-gatedcurrents(Ki=0.03µM).Showsanticonvulsantactions.Blood-brainbarrierpermeable.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylicacidhydrochloride
- MolecularWeight371.91
- Chemicalstructure
![SKF 89976A hydrochloride [85375-15-1]](images/hellobio/201710/hb0976.png "SKF 89976A hydrochloride [85375-15-1]")
- MolecularFormulaC22H25NO2.HCl
- CASNumber85375-15-1
StoringandUsingYourProduct
- Storageinstructions+4°C(desiccate)
- Solubilityoverviewsolubleinwater(100mM,gentlewarming)orDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforSKF89976Ahydrochloride
IdentificationandselectiveinhibitionofthechannelmodeoftheneuronalGABAtransporter1.
KrauseSetal(2005)MolPharmacol68(6):1728-35.PubMedID:16150932Orallyactiveandpotentinhibitorsofgamma-aminobutyricaciduptake.
AliFEetal(1985)JMedChem28(5):653-60.PubMedID:2985785ComparisonoftheanticonvulsanteffectsoftwonovelGABAuptakeinhibitorsanddiazepaminamygdaloidkindledrats.
SchwarkWSetal(1985)NaunynSchmiedebergsArchPharmacol329(4):367-71.PubMedID:4033806
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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