Hello Bio/SKF 89976A hydrochloride/HB0976/50mg
市场价：
¥6981.00
美元价：
5370.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameSKF 89976A hydrochloride
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Short descriptionPotent, selective, competitive GAT-1 GABA uptake inhibitor
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Biological descriptionPotent, selective and competitive GAT-1 GABA uptake inhibitor. Selective for GAT-1 over GAT-2, GAT-3 and BGT-1 (IC50 values are 0.13, 550, 944 and 7210 µM respectively). Inhibits GABA uptake (Ki = 7 µM) and transmitter-gated currents (Ki = 0.03 µM). Shows anticonvulsant actions. Blood-brain barrier permeable.
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Biological actionInhibitor
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Purity>99%
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Properties
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Chemical name1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
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Molecular Weight371.91
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Chemical structure
![SKF 89976A hydrochloride [85375-15-1]](images/hellobio/201710/hb0976.png "SKF 89976A hydrochloride [85375-15-1]")
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Molecular FormulaC22H25NO2.HCl
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CAS Number85375-15-1
Storing and Using Your Product
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Storage instructions+4°C (desiccate)
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Solubility overviewsoluble in water (100mM, gentle warming) or DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for SKF 89976A hydrochloride
Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1.
Krause S et al (2005) Mol Pharmacol 68(6) : 1728-35.PubMedID: 16150932Orally active and potent inhibitors of gamma-aminobutyric acid uptake.
Ali FE et al (1985) J Med Chem 28(5) : 653-60.PubMedID: 2985785Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats.
Schwark WS et al (1985) Naunyn Schmiedebergs Arch Pharmacol 329(4) : 367-71.PubMedID: 4033806
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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