Hello Bio/Scriptaid/HB1398/50mg
市场价：
¥5401.50
美元价：
4155.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameScriptaid
- ShortdescriptionPotentHDACinhibitor
- BIOLOGicaldescriptionPotenthistonedeacetylase(HDAC)inhibitor(IC50valuesare0.64,1.4,14.5,34and607nMforHDAC1,8,6and3respectively).IncreasesexpressionofestrogenreceptorαinbreastcancercellsandreactivateslatentHIVinfection.Showsgrowthinhibitory,anti-cancerandneuroprotectiveactions.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide
- MolecularWeight326.35
- Chemicalstructure
![Scriptaid [287383-59-9]](images/hellobio/201710/hb1398.png "Scriptaid [287383-59-9]")
- MolecularFormulaC18H18N2O4
- CASNumber287383-59-9
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforScriptaid
Anovelhistonedeacetylaseinhibitor,scriptaid,enhancesexpressionoffunctionalestrogenreceptoralpha(ER)inERnegativehumanbreastcancercellsincombinationwith5-aza2"-deoxycytidine.
KeenJCetal(2003)BreastCancerResTreat81(3):177-86.PubMedID:14620913Inhibitorsofhistonedeacetylases:correlationbetweenisoformspecificityandreactivationofHIVtype1(HIV-1)fromlatentlyinfectedcells.
HuberKetal(2011)JBiolChem286(25):22211-8.PubMedID:21531716Scriptaid,anovelhistonedeacetylaseinhibitor,protectsagainsttraumaticbraininjuryviamodulationofPTENandAKTpathway:scriptaidprotectsagainstTBIviaAKT.
WangGetal(2013)Neurotherapeutics10(1):124-42.PubMedID:23132328
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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