你好Bio/SCH 23390盐酸盐/HB1643/10mg
市场价：
¥2086.50
美元价：
1605.00
产品分类：
酸碱缓冲液
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3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameSCH 23390 hydrochloride
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Short descriptionPotent, selective D1-like receptor antagonist
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Biological descriptionPotent and selective D1-like receptor antagonist (Ki values are 0.2, 0.3, ~800, ~1100, ~3000 nM at D1, D5, D3, D2 and D4 respectively). Also acts as an agonist at 5-HT1C and 5-HT2C (Ki values are 6.3 and 9.3 respectively). Shows anxiolytic and anticonvulsant effects. Active in vivo.
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Biological actionAntagonist
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Purity>98%
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Properties
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Chemical name(R)-(+)-7-Chloro-8-hydroxy-3-methyl -1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
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Molecular Weight324.24
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Chemical structure
![SCH 23390 hydrochloride [125941-87-9]](images/hellobio/201710/hb1643.png "SCH 23390 hydrochloride [125941-87-9]")
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Molecular FormulaC17H18ClNO.HCl
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CAS Number125941-87-9
Storing and Using Your Product
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Storage instructions+4°C (desiccate)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for SCH 23390 hydrochloride
The 'selective' dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist at cloned human serotonin2C receptors.
Millan MJ et al (2001) Psychopharmacology (Berl) 156(1) : 58-62.PubMedID: 11465634SCH 23390: the first selective dopamine D1-like receptor antagonist.
Bourne JA (2001) CNS Drug Rev 7(4) : 399-414.PubMedID: 11830757Selective blockade of dopamine D-1 receptor by SCH 23390 affects dopamine agonist binding to 3H-spiperone labeled D-2 receptors in rat striatum.
Zhang X et al (1989) Jpn J Pharmacol 50(3) : 333-45.PubMedID: 2569545
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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