你好Bio/SB 431542/HB3555/50mg
市场价：
¥8248.50
美元价：
6345.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameSB 431542
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Short descriptionPotent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells.
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Biological description
Potent and selective transforming growth factor β type I receptor (TGF-βRI) actvin receptor-like kinase ALK5, ALK4 and ALK7 inhibitor (IC50 = 94 nM at ALK5).
Specifically inhibits Smad2/3 activation and blocks TGF-β signal transduction.
Maintains the undifferentiated state of mouse embryonic stem cells (ESCs).
Also induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells.
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Biological actionInhibitor
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Purity>98%
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Properties
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Chemical name4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide
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Molecular Weight384.4
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Chemical structure
![SB 431542 [301836-41-9]](images/hellobio/201710/hb3555.png "SB 431542 [301836-41-9]")
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Molecular FormulaC22H16N4O3
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CAS Number301836-41-9
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PubChem identifier4521392
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SMILESC1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
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SourceSynthetic
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InChiInChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
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InChiKeyFHYUGAJXYORMHI-UHFFFAOYSA-N
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MDL numberMFCD11045982
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AppearanceYellow solid
Storing and Using Your Product
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Storage instructionsRoom temperature
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Solubility overviewSoluble in DMSO (100mM) and ethanol (10mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for SB 431542
Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.
Laping et al (2002) Mol Pharmacol 62(1) : 58-64PubMedID: 12065755SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.
Inman et al (2002) Mol Pharmacol 62(1) : 65-74PubMedID: 12065756TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells.
Watabe et al (2003) J Cell Biol 163(6) : 1303-11PubMedID: 14676305Mechanism of SB431542 in inhibiting mouse embryonic stem cell differentiation.
Du et al (2014) Cell Signal 26(10) : 2107-16PubMedID: 24949833
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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