你好Bio/SB 431542/HB3555/10mg
市场价：
¥1930.50
美元价：
1485.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameSB431542
- ShortdescriptionPotent,selectiveTGF-βRIALK5,ALK4,ALK7inhibitor.Inducessheetformation,proliferation,differentiationofESC-derivedendothelialcells.
- BIOLOGicaldescription
PotentandselectivetransforminggrowthfactorβtypeIreceptor(TGF-βRI)actvinreceptor-likekinaseALK5,ALK4andALK7inhibitor(IC50=94nMatALK5).
SpecificallyinhibitsSmad2/3activationandblocksTGF-βsignaltransduction.
Maintainstheundifferentiatedstateofmouseembryonicstemcells(ESCs).
Alsoinducessheetformation,proliferation,differentiationofESC-derivedendothelialcells.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide
- MolecularWeight384.4
- Chemicalstructure
![SB 431542 [301836-41-9]](images/hellobio/201710/hb3555.png "SB 431542 [301836-41-9]")
- MolecularFormulaC22H16N4O3
- CASNumber301836-41-9
- PubChemidentifier4521392
- SMILESC1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
- SourceSynthetic
- InChiInChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
- InChiKeyFHYUGAJXYORMHI-UHFFFAOYSA-N
- MDLnumberMFCD11045982
- AppearanceYellowsolid
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinDMSO(100mM)andethanol(10mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforSB431542
Inhibitionoftransforminggrowthfactor(TGF)-beta1-inducedextracellularmatrixwithanovelinhibitoroftheTGF-betatypeIreceptorkinaseactivity:SB-431542.
Lapingetal(2002)MolPharmacol62(1):58-64PubMedID:12065755SB-431542isapotentandspecificinhibitoroftransforminggrowthfactor-betasuperfamilytypeIactivinreceptor-likekinase(ALK)receptorsALK4,ALK5,andALK7.
Inmanetal(2002)MolPharmacol62(1):65-74PubMedID:12065756TGF-betareceptorkinaseinhibitorenhancesgrowthandintegrityofembryonicstemcell-derivedendothelialcells.
Watabeetal(2003)JCellBiol163(6):1303-11PubMedID:14676305MechanismofSB431542ininhibitingmouseembryonicstemcelldifferentiation.
Duetal(2014)CellSignal26(10):2107-16PubMedID:24949833
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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