你好Bio/SB 269970盐酸盐/HB1684/50mg
市场价：
¥11134.50
美元价：
8565.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameSB269970hydrochloride
- ShortdescriptionPotent,selective5-HT7receptorantagoNIST
- BIOLOGicaldescriptionPotentandselective5-HT7receptorantagonist.Selectiveforfor5-HT7Aover5-HT5Aand5-HT1B(pKivaluesare8.9,7.2and6.0respectively).Inhibitshyperactivityinducedbyamphetamineandketamine.Blood-brainbarrierpermeable.
- AlternativenamesSB-269970,SB269970
- BiologicalactionAntagonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidinehydrochloride
- MolecularWeight388.95
- Chemicalstructure
![SB 269970 hydrochloride [261901-57-9]](images/hellobio/201710/hb1684.png "SB 269970 hydrochloride [261901-57-9]")
- MolecularFormulaC18H28N2O3S.HCl
- CASNumber261901-57-9
StoringandUsingYourProduct
- Storageinstructions+4°C
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforSB269970hydrochloride
CharacterizationofSB-269970-A,aselective5-HT(7)receptorantagonist.
HaganJJetal(2000)BrJPharmacol130(3):539-48.PubMedID:10821781EffectsofSB-269970,a5-HT7receptorantagonist,inmousemodelspredictiveofantipsychotic-likeactivity.
GaliciRetal(2008)BehavPharmacol19(2):153-9.PubMedID:18332680Anovel,potent,andselective5-HT(7)antagonist:(R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol(SB-269970).
LovellPJetal(2000)JMedChem43(3):342-5.PubMedID:10669560Effectsoftheselective5-HT7receptorantagonistSB-269970andamisulprideonketamine-inducedschizophrenia-likedeficitsinrats.
NikiforukAetal(2013)PLoSOne8(6):e66695.PubMedID:23776692
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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