Hello Bio/SB 269970 hydrochloride/HB1684/10mg
市场价：
¥2847.00
美元价：
2190.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameSB 269970 hydrochloride
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Short descriptionPotent, selective 5-HT7 receptor antagonist
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Biological descriptionPotent and selective 5-HT7 receptor antagonist. Selective for for 5-HT7A over 5-HT5A and 5-HT1B (pKi values are 8.9, 7.2 and 6.0 respectively). Inhibits hyperactivity induced by amphetamine and ketamine. Blood-brain barrier permeable.
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Alternative namesSB-269970,SB269970
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Biological actionAntagonist
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Purity>98%
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Properties
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Chemical name(2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine hydrochloride
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Molecular Weight388.95
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Chemical structure
![SB 269970 hydrochloride [261901-57-9]](images/hellobio/201710/hb1684.png "SB 269970 hydrochloride [261901-57-9]")
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Molecular FormulaC18H28N2O3S.HCl
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CAS Number261901-57-9
Storing and Using Your Product
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Storage instructions+4°C
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for SB 269970 hydrochloride
Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist.
Hagan JJ et al (2000) Br J Pharmacol 130(3) : 539-48.PubMedID: 10821781Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity.
Galici R et al (2008) Behav Pharmacol 19(2) : 153-9.PubMedID: 18332680A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).
Lovell PJ et al (2000) J Med Chem 43(3) : 342-5.PubMedID: 10669560Effects of the selective 5-HT7 receptor antagonist SB-269970 and amisulpride on ketamine-induced schizophrenia-like deficits in rats.
Nikiforuk A et al (2013) PLoS One 8(6) : e66695.PubMedID: 23776692
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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