Hello Bio/SB 216763/HB1272/50mg
市场价：
¥9730.50
美元价：
7485.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameSB 216763
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Short descriptionPotent, selective cell permeable GSK-3 inhibitor. Promotes mouse ESC pluripotency.
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Biological descriptionPotent and selective cell permeable, ATP competitive GSK-3 inhibitor (IC50 = 34 nM for GSK-3α). Equally effective at GSK-3α as GSK-3β. Displays little or no activity at 24 other serine/threonine and tyrosine protein kinases. Additionally stimulates glycogen synthesis (EC50 = 3.6 μM). Also promotes mouse embryonic stem cell pluripotency and displays anti-inflammatory and neuroprotective properties.
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Alternative namesSB-216763
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Biological actionInhibitor
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
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Molecular Weight371.22
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Molecular FormulaC19H12Cl2N2O2
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CAS Number280744-09-4
Storing and Using Your Product
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Storage instructionsroom temperature
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Solubility overviewsoluble in DMSO (75mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for SB 216763
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.
Coghlan MP et al (2000) Chem Biol 7(10) : 793-803.PubMedID: 110330823-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis.
Gurrieri C et al (2010) J Pharmacol Exp Ther 332(3) : 785-94.PubMedID: 19959748Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death.
Cross DA et al (2001) J Neurochem 77(1) : 94-102.PubMedID: 11279265
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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