你好Bio/SB 216763/HB1272/10mg
市场价：
¥2340.00
美元价：
1800.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameSB216763
- ShortdescriptionPotent,selectivecellpermeableGSK-3inhibitor.PromotesmouseESCpluripotency.
- BIOLOGicaldescriptionPotentandselectivecellpermeable,ATPcompetitiveGSK-3inhibitor(IC50=34nMforGSK-3α).EquallyeffectiveatGSK-3αasGSK-3β.Displayslittleornoactivityat24otherserine/threonineandtyrosineproteinkinases.Additionallystimulatesglycogensynthesis(EC50=3.6μM).Alsopromotesmouseembryonicstemcellpluripotencyanddisplaysanti-inflammatoryandneuroprotectiveproperties.
- AlternativenamesSB-216763
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
- MolecularWeight371.22
- MolecularFormulaC19H12Cl2N2O2
- CASNumber280744-09-4
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinDMSO(75mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforSB216763
Selectivesmallmoleculeinhibitorsofglycogensynthasekinase-3modulateglycogenmetabolismandgenetranscription.
CoghlanMPetal(2000)ChemBiol7(10):793-803.PubMedID:110330823-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione(SB216763),aglycogensynthasekinase-3inhibitor,displaystherapeuticpropertiesinamousemodelofpulmonaryinflammationandfibrosis.
GurrieriCetal(2010)JPharmacolExpTher332(3):785-94.PubMedID:19959748Selectivesmall-moleculeinhibitorsofglycogensynthasekinase-3activityprotectprimaryneuronesfromdeath.
CrossDAetal(2001)JNeuRochem77(1):94-102.PubMedID:11279265
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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