Hello Bio/SB 203580/HB1302/
市场价：
¥585.00
美元价：
450.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameSB203580
- ShortdescriptionPotent,selectivep38MAPKinhibitor.Stimulatesneuralstemcellproliferation.
- BIOLOGicaldescriptionPotentandselectivep38MAPKinhibitor(IC50valuesare32.6and22.4nMforactiveandinactiveformsofp38respectively).Exhibitshigherselectivityforp38αoverp38β(IC50valuesare50and500nMrespectively).Inhibitsmanykinasesincludingtyrosinekinasesp56lckandc-src(IC50=5µM)andalsoTNFα,IL-6,COX-1,COX-2.Alsostimulatesneuralstemcellproliferation.Displaysanti-inflammatoryproperties.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine
- MolecularWeight377.44
- Chemicalstructure
![SB 203580 [152121-47-6]](images/hellobio/201710/hb1302.png "SB 203580 [152121-47-6]")
- MolecularFormulaC21H16FN3OS
- CASNumber152121-47-6
StoringandUsingYourProduct
- Storageinstructions+4°C(desiccate)
- SolubilityoverviewsolubleinDMSO(25mM)orHCl(100mM,1eq.HCl)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforSB203580
Specificityandmechanismofactionofsomecommonlyusedproteinkinaseinhibitors.
DaviesSPetal(2000)BiochemJ351(Pt1):95-105.PubMedID:10998351Novelp38MAPKinhibitorML3403haspotentanti-inflammatoryactivityinairwaysmoothmuscle.
MunozLetal(2010)EurJPharmacol635(1-3):212-8.PubMedID:20226180RWJ67657,apotent,orallyactiveinhibitorofp38mitogen-activatedproteinkinase.
WadsworthSAetal(1999)JPharmacolExpTher291(2):680-7.PubMedID:10525088Directinhibitionofcyclooxygenase-1and-2bythekinaseinhibitorsSB203580andPD98059.SB203580alsoinhibitsthromboxanesynthase.
Börsch-HauboldAGetal(1998)JBiolChem273(44):28766-72.PubMedID:9786874
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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