Hello Bio/SB 202190/HB1301/100mg
市场价：
¥9691.50
美元价：
7455.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameSB202190
- ShortdescriptionPotentATPcompetitivep38MAPKinhibitor
- BIOLOGicaldescriptionPotentATPcompetitivep38MAPKinhibitor(IC50valuesare50and100nMforp38αandp38βrespectively).InhibitsTNF,IL-1andCK1(approxIC50=0.6μM)thereforeinhibitsCREBphosphorylation.ExhibitslittleornoactivityatCK2.Displaysanti-inflammatorypropertiesandinducesapoptosis.
- AlternativenamesSB-202190
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol
- MolecularWeight331.35
- Chemicalstructure
![SB 202190 [152121-30-7]](images/hellobio/201710/hb1301.png "SB 202190 [152121-30-7]")
- MolecularFormulaC20H14N3OF
- CASNumber152121-30-7
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforSB202190
Non-specificinvivoinhibitionofCK1bythepyridinylimidazolep38inhibitorsSB203580andSB202190.
ShanwareNPetal(2009)BMBRep42(3):142-7.PubMedID:19336000Specificityandmechanismofactionofsomecommonlyusedproteinkinaseinhibitors.
DaviesSPetal(2000)BiochemJ351(Pt1):95-105.PubMedID:10998351InductionofapoptosisbySB202190throughinhibitionofp38betamitogen-activatedproteinkinase.
NemotoSetal(1998)JBiolChem273(26):16415-20.PubMedID:9632706
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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