Hello Bio/Salvinorin A/HB2400/1mg
市场价：
¥1755.00
美元价：
1350.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameSalvinorin A
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Short descriptionPotent, selective κ opioid receptor (KOP) agonist
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Biological descriptionPotent, selective κ opioid receptor (KOP) agonist (Ki = 4.3 nM). Isolated from Salvia divinorum. Only non-nitrogenous κ opioid agonist, lacks chemical features associated with opiate ligand activity. Also acts as an allosteric modulator of μ opioid receptors. Shows psychoactive activity. Active in vivo.
Not for sale in the US or Canada -
Alternative namesDivinorin A, SALA
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Biological actionAntagonist
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Properties
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Chemical name(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
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Molecular Weight432.5
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Chemical structure
![Salvinorin A [83729-01-5]](images/hellobio/201710/hb2400.png "Salvinorin A [83729-01-5]")
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Molecular FormulaC23H28O8 · 0.25H2O
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CAS Number83729-01-5
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PubChem identifier128563
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SMILESCC(=O)O[C@H]1C[C@H]([C@@]2(CC[C@H]3C(=O)O[C@@H](C[C@@]3([C@H]2C1=O)C)C4=COC=C4)C)C(=O)OC
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SourceExtracted from Salvia divinorum
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InChiInChI=1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1
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InChiKeyOBSYBRPAKCASQB-AGQYDFLVSA-N
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MDL numberMFCD05664742
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AppearanceWhite solid
Storing and Using Your Product
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Solubility overviewSoluble in ethanol (20 mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Salvinorin A
Salvinorin A: allosteric interactions at the mu-opioid receptor.
Rothman et al (2007) J Pharmacol Exp Ther 320(2) : 801-10PubMedID: 17060492A unique binding epitope for salvinorin A, a non-nitrogenous kappa opioid receptor agonist.
Kane et al (2006) FEBS J 273(9) : 1966-74PubMedID: 16640560Salvinorin A: the "magic mint" hallucinogen finds a molecular target in the kappa opioid receptor.
Sheffler and Roth (2003) Trends Pharmacol Sci. 24(3) : 107-9PubMedID: 12628350
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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