你好Bio/Salubrinal/HB0573/25mg
市场价：
¥4953.00
美元价：
3810.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameSalubrinal
- ShortdescriptionSelectiveelF2αdephosphorylationinhibitor
- BIOLOGicaldescriptionSelectiveeukaryotictranslationinitiationfactor2subunitα(elF2α)dephosphorylationinhibitor.Inhibitsproteinphosphatase1(PP1)actiononelF2αwithoutinhibitingdephosphorylationofotherPP1substrates.Inhibitherpessimplexvirusreplicationandprotectscellsfromapoptosisthroughendoplasmicreticulumstress.Showspotentialneuroprotectiveactions.
- AlternativenameseIF-2αInhibitor
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
- MolecularWeight479.81
- Chemicalstructure
![Salubrinal [405060-95-9]](images/hellobio/201710/hb0573.png "Salubrinal [405060-95-9]")
- MolecularFormulaC21H17N4OSCl3
- CASNumber405060-95-9
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforSalubrinal
AselectiveinhibitorofeIF2alphadephosphorylationprotectscellsfromERstress.
BoyceMetal(2005)Science307(5711):935-9.PubMedID:15705855Apharmacoproteomicapproachimplicateseukaryoticelongationfactor2kinaseinERstress-inducedcelldeath.
BoyceMetal(2008)CellDeathDiffer15(3):589-99.PubMedID:18188169Endoplasmicreticulumstressplayscriticalroleinbraindamageafterchronicintermittenthypoxiaingrowingrats.
CaiXHetal(2014)ExpNeurol257:148-56.PubMedID:24810321
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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