Hello Bio/Ryanodine/HB1320/1mg
市场价：
¥2905.50
美元价：
2235.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameRyanodine
- ShortdescriptionPotentCa2+releaseinhibitor
- BIOLOGicaldescriptionPotentCa2+releaseinhibitor.Inhibitsreleasefromthecardiacandskeletalmusclesarcoplasmicreticulum(IC50valuesare2.8and10nMrespectively).Showsactionstoslowarrhythmiadevelopmentinheartfailure.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname1H-Pyrrole-2-carboxylicacid,(3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-ylester
- MolecularWeight493.55
- Chemicalstructure
![Ryanodine [15662-33-6]](images/hellobio/201710/hb1320.png "Ryanodine [15662-33-6]")
- MolecularFormulaC25H35NO9
- CASNumber15662-33-6
- PubChemidentifier11317883
- SMILESCC(C)[C@@]6(O)C(OC(=O)c1cccn1)[C@]2(O)[C@@]5(O)[C@@]34O[C@@](O)(C[C@@]2(C)[C@@]4(O)CC[C@H](C)[C@H]3O)[C@]56C
- SourceExtractedfromryaniaspeciosa
- InChiInChI=1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19+,20-,21-,22+,23+,24+,25+/m0/s1
- InChiKeyJJSYXNQGLHBRRK-SFEDZAPPSA-N
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewSolubleinethanol(10mM)andinDMSO(25mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforRyanodine
Thepharmacologyofryanodineandrelatedcompounds.
SutkoJLetal(1997)PharmacolRev49(1):53-98.PubMedID:9085309EffectsofsarcolemmalCa(2+)entry,ryanodinefunction,andkinaseinhibitorsonarabbitmodelofheartfailure.
KijtawornratAetal(2010)IntHeartJ51(4):285-90.PubMedID:20716847RyanodinemodificationofRyR1retrogradelyaffectsL-typeCa(2+)channelgatinginskeletalmuscle.
BanNISTerRAetal(2009)JMuscleResCellMotil30(5-6):217-23.PubMedID:19802526
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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