Hello Bio/RWJ 67657/HB1300/1mg
市场价：
¥858.00
美元价：
660.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameRWJ67657
- ShortdescriptionPotentp38MAPKinhibitor
- BIOLOGicaldescriptionPotentp38MAPKinhibitor(IC50valuesare1.0and11µMforp38αandβsubunitsrespectively).Exhibitsnoactivityatp38γorδsubunits.PotentlyinhibitsTNFα,IL-1βandIL-8production(IC50valuesare15,11and30nMrespectively).AlsoinhibitsIL-6,IL-8,MMP3,COX-2mRNAandHIVreplication.Displaysanti-inflammatoryandcardioprotectiveproperties.Approx10-foldmorepotentthanSB203580.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol
- MolecularWeight425.5
- MolecularFormulaC27H24FN3O
- CASNumber215303-72-3
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforRWJ67657
StronginhibitionofTNF-alphaproductionandinhibitionofIL-8andCOX-2mRNAexpressioninmonocyte-derivedmacrophagesbyRWJ67657,ap38mitogen-activatedproteinkinase(MAPK)inhibitor.
WestraJetal(2004)ArthritisResTher6(4):R384-92.PubMedID:15225374RWJ67657,apotent,orallyactiveinhibitorofp38mitogen-activatedproteinkinase.
WadsworthSAetal(1999)JPharmacolExpTher291(2):680-7.PubMedID:10525088p38mitogen-activatedproteinkinaseinhibitionimprovescardiacfunctionandattenuatesleftventricularremodelingfollowingmyocardialinfarctionintherat.
SeeFetal(2004)JAmCollCardiol44(8):1679-89.PubMedID:15489104SuppressionofHIV-1viralreplicationandcellularpathogenesisbyanovelp38/JNKkinaseinhibitor.
MuthumaniKetal(2004)AIDS18(5):739-48.PubMedID:15075508
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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