Hello Bio/Rottlerin/HB0561/50mg
市场价：
¥5265.00
美元价：
4050.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameRottlerin
- ShortdescriptionPKCinhibitor
- BIOLOGicaldescriptionProteinkinaseCinhibitor(IC50=3-6µMforPKC-δ).InhibitscAM-kinaseIII,PRAK(IC50=1.9µM)andMAPKAP-K2(IC50=5.4µM).Novellipoproteinreceptor-relatedprotein-6(LRP6)inhibitor.AlsosuppressesWnt/β-cateninandmTORC1signalling.Displayscellgrowthsuppressing,apoptosisinducingandanti-angiogenesisproperties.
- BiologicalactionInhibitor
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname3"-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2",4",6"-trihydroxy-5"-methylacetophenone
- MolecularWeight516.55
- Chemicalstructure
![Rottlerin [82-08-6]](images/hellobio/201710/hb0561.png "Rottlerin [82-08-6]")
- MolecularFormulaC30H28O8
- CASNumber82-08-6
- PubChemidentifier5281847
- SMILESCC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C3=C(C(=C2O)C(=O)/C=C/C4=CC=CC=C4)OC(C=C3)(C)C)O)O
StoringandUsingYourProduct
- Storageinstructions+4°C
- Solubilityoverviewsolubleinethanol(2mM,gentlewarming)orDMSO(20mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforRottlerin
RottlerininducesWntco-receptorLRP6degradationandsuppressesbothWnt/β-cateninandmTORC1signalinginprostateandbreastcancercells.
LuWetal(2014)CellSignal26(6):1303-9.PubMedID:24607787Specificityandmechanismofactionofsomecommonlyusedproteinkinaseinhibitors.
DaviesSPetal(2000)BiochemJ351(Pt1):95-105.PubMedID:10998351Rottlerin,anovelproteinkinaseinhibitor.
GschwendtMetal(1994)BiochemBiophysResCommun199(1):93-8.PubMedID:8123051DeterminationofRottlerin,aNaturalProteinKinasesCInhibitor,inPancreaticCancerCellsandMouseXenograftsbyRP-HPLCMethod.
LuQYetal(2013)JChromatogrSepTech4(1):PubMedID:24482742
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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