Hello Bio/Ro-32-0432/HB0560/1mg
市场价：
¥2847.00
美元价：
2190.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameRo-32-0432
- ShortdescriptionPotent,selectivePKCinhibitor
- BIOLOGicaldescriptionPotentandselectiveproteinkinaseCinhibitor(IC50valuesare21,9,28,31,37and108nMforPKC,PKC-α,PKC-β1,PKC-β2,PKC-γandPKC-εrespectively).Displays10-and4-foldselectivityforPKC-αandPKC-β1overPKC-εrespectively.AlsoaGprotein-coupledreceptorkinase5inhibitor.Cellpermeable.Displaysanti-inflammatoryproperties.
- BiologicalactionInhibitor
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameBisindolylmaleimideXIhydrochloride
- MolecularWeight489.01
- MolecularFormulaC28H28N4O2HCl
- CASNumber151342-35-7
- PubChemidentifier11605551
- SMILESCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C5CC(CCN5C6=CC=CC=C64)CN(C)C.Cl
StoringandUsingYourProduct
- SolubilityoverviewsolubleinDMSO
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforRo-32-0432
Ro32-0432,aselectiveandorallyactiveinhibitorofproteinkinaseCpreventsT-cellactivation.
BirchallAMetal(1994)JPharmacolExpTher268(2):922-9.PubMedID:8114006Isoenzymespecificityofbisindolylmaleimides,selectiveinhibitorsofproteinkinaseC.
WilkinsonSEetal(1993)BiochemJ294(Pt2):335-7.PubMedID:8373348Ro32-0432attenuatesmecamylamine-precipitatednicotinewithdrawalsyndromeinmice.
SinghTGetal(2013)NaunynSchmiedebergsArchPharmacol386(3):197-204.PubMedID:23274455
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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