Hello Bio/Ro 25-6981 maleate/HB0554/1mg
市场价：
¥838.50
美元价：
645.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameRo25-6981maleate
- ShortdescriptionSelectivenegativeallostericmodulatorofGluN2B(NR2B)containingNMDARs
- BIOLOGicaldescription
SelectivenegativeallostericmodulatorofGluN2B(NR2B)containingNMDARs.
Exhibits>5000-foldselectivityatGluN1C-GluN2BoverGluN1C-GluN2A(IC50valuesare9nMand52µM).Showsneuroprotectiveproperties.
- BiologicalactionNAM
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanolmaleate
- MolecularWeight455.55
- Chemicalstructure
![Ro 25-6981 [1312991-76-6]](images/hellobio/201710/hb0554.png "Ro 25-6981 [1312991-76-6]")
- MolecularFormulaC22H29NO2.C4H4O4
- CASNumber1312991-76-6
- PubChemidentifier53250677
- SMILESC[C@@H](CN1CCC(CC1)CC2=CC=CC=C2)[C@H](C3=CC=C(C=C3)O)O.C(=CC(=O)O)C(=O)O
- SourceSynthetic
- InChiInChI=1S/C22H29NO2.C4H4O4/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;5-3(6)1-2-4(7)8/h4-10,17,19,22,24-25H,11-16H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t17-,22+;/m0./s1
- InChiKeyFYJZEHCQSUBZDY-SEELMCCHSA-N
- MDLnumberMFCD06798375
- AppearanceWhitesolid
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature(desiccate)
- SolubilityoverviewSolubleinwater(10mM,gentlewarming)andinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforRo25-6981maleate
Ro25-6981,ahighlypotentandselectiveblockerofN-methyl-D-aspartatereceptorscontainingtheNR2Bsubunit.Characterizationinvitro.
FischerGetal(1997)JPharmacolExpTher283(3):1285-92.PubMedID:9400004TheNR2B-selectiveN-methyl-D-aspartatereceptorantagoNISTRo25-6981[(+/-)-(R*,S*)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanol]potentiatestheeffectofnicotineonlocomotoractivityanddopaminereleaseinthenucleus
KosowskiARetal(2004)JPharmacolExpTher311(2):560-7.PubMedID:15256539PharmacologicalcharacterizationofinteractionsofRO25-6981withtheNR2B(epsilon2)subunit.
LynchDRetal(2001)EurJPharmacol416(3):185-95.PubMedID:11290368
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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