Hello Bio/RN 1734/HB1196/25mg
市场价：
¥3256.50
美元价：
2505.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameRN1734
- ShortdescriptionTRPV4channelantagoNIST
- BIOLOGicaldescriptionTRPV4channelantagonist(IC50valuesare2.3,3.2and5.9µMforhTRPV4,rTRPV4andmTRPV4).ExhibitshigherselectivityforTRPV4overTRPV1,TRPV3andTRPM8channels(IC50values=>30µM).AlsoblocksATP-sensitiveK+channels.
- BiologicalactionAntagonist
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide
- MolecularWeight353.31
- Chemicalstructure
![RN 1734 [946387-07-1]](images/hellobio/201710/hb1196.png "RN 1734 [946387-07-1]")
- MolecularFormulaC14H22Cl2N2O2S
- CASNumber946387-07-1
- PubChemidentifier3601086
- SMILESCC(C)NCCN(C(C)C)S(=O)(=O)C1=C(C=C(C=C1)Cl)Cl
- InChiInChI=1S/C14H22Cl2N2O2S/c1-10(2)17-7-8-18(11(3)4)21(19,20)14-6-5-12(15)9-13(14)16/h5-6,9-11,17H,7-8H2,1-4H3
- InChiKeyIHYZMEAZAIFMTN-UHFFFAOYSA-N
- MDLnumberMFCD00129453
- AppearanceWhitesolid
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewSolubleinDMSO(100mM)andinethanol(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforRN1734
IdentificationandcharacterizationofnovelTRPV4modulators.
VincentFetal(2009)BiochemBiophysResCommun389(3):490-4.PubMedID:19737537LowintravascularpressureactivatesendothelialcellTRPV4channels,localCa2+events,andIKCachannels,reducingarteriolartone.
BagherPetal(2012)ProcNatlAcadSciUSA109(44):18174-9.PubMedID:23071308
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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