Hello Bio/RG 108/HB1377/50mg
市场价：
¥7332.00
美元价：
5640.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameRG108
- ShortdescriptionNon-nucleosideDNAmethyltransferaseinhibitor.EnhancesiPSCgenerationefficiency.
- BIOLOGicaldescriptionNon-nucleosideDNAmethyltransferase(DNMT)inhibitor(IC50=115nM).Bindsattheactivesite.Causeshypomethylationandreactivatestumorsuppressorgenes.Showsgrowthinhibitingandpro-apoptoticanti-canceractions.AlsoenhancesiPSCgenerationefficiency.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-Phthalyl-L-tryptophan
- MolecularWeight334.33
- Chemicalstructure
![RG 108 [48208-26-0]](images/hellobio/201710/hb1377.png "RG 108 [48208-26-0]")
- MolecularFormulaC19H14N2O4
- CASNumber48208-26-0
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforRG108
Epigeneticreactivationoftumorsuppressorgenesbyanovelsmall-moleculeinhibitorofhumanDNAmethyltransferases.
BruecknerBetal(2005)CancerRes65(14):6305-11.PubMedID:16024632Anti-tumoraleffectofthenon-nucleosideDNMTinhibitorRG108inhumanprostatecancercells.
Graã?aIetal(2014)CurrPharmDes20(11):1803-11.PubMedID:23888969FunctionaldiversityofDNAmethyltransferaseinhibitorsinhumancancercelllines.
StresemannCetal(2006)CancerRes66(5):2794-800.PubMedID:16510601
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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