Hello Bio/Rapamycin/HB2779/
市场价：
¥2847.00
美元价：
2190.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameRapamycin
- ShortdescriptionmTORinhibitorandpotentimmunosuppressant
- BIOLOGicaldescription
mTORinhibitorandpotentimmunosuppressant.
ComplexeswithFKBP12tobindmTORC1toinhibitmTORactivityandblocksubsequentactivationofp70s6kinase(IC50=50pM).
Inducesautophagyandapoptosis.
PromoteshPSCdifferentiationtobloodProgenitorandmesendodermcells.
RapamycincanalsobeusedininducIBLeCRISPR/Cas9systemstoenableinduciblegeneediting.
Activeinvivo.
- AlternativenamesSirolimus
- BiologicalactionAntibiotic
- Modeofactioninterfereswithprotiensynthesisbyenzymeinhibition
- AntibioticSpectrumyeastandfungi
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
- MolecularWeight914.18
- MolecularFormulaC51H79NO13
- CASNumber53123-88-9
- PubChemidentifier5284616
- SMILESC[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC
- InChiKeyQFJCIRLUMZQUOT-HPLJOQBZSA-N
- MDLnumberMFCD00867594
- AppearanceWhitetooff-white
StoringandUsingYourProduct
- Storageinstructions-20°C;
- SolubilityoverviewSolubleinethanol(20mM)andDMSO(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforRapamycin
Rapamycin,aspecificinhibitorofthemammaliantargetofrapamycin,suppresseslymphangiogenesisandlymphaticmetastasis.
Kobayashietal(2007)CancerSci98(5):726-33PubMedID:17425689Rapamycins:mechanismofactionandcellularresistance.
Huangetal(2003)CancerBiolTher2(3):222-32PubMedID:12878853Chemicalmodulatorsofautophagyasbiologicalprobesandpotentialtherapeutics.
Fleminetal(2011)NatChemBiol7(1):9-17PubMedID:21164513Asplit-Cas9architectureforinduciblegenomeeditingandtranscriptionmodulation.
Zetscheetal(2015)NatBiotechnol33(2):139-42PubMedID:25643054
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
