Hello Bio/QNZ 46/HB0541/
市场价：
¥721.50
美元价：
555.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameQNZ46
- ShortdescriptionGluN2C/Dselective,non-competitiveNMDAreceptorantagoNIST
- BIOLOGicaldescriptionGluN2C/D(NR2C/NR2D)selective,non-competitiveNMDAreceptorantagonist(IC50valuesare182,193,7.1and3.9µMforGluN2A,GluN2B,GluN2CandGluN2Drespectively).Bindstoglutamatesite.Approx50-foldmoreselectiveforGluN2C/DthanGluN2A/B.
- BiologicalactionAntagonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)quinazolinyl]benzoicacid
- MolecularWeight443.41
- Chemicalstructure
![QNZ 46 [1237744-13-6]](images/hellobio/201710/hb0541.png "QNZ 46 [1237744-13-6]")
- MolecularFormulaC24H17N3O6
- CASNumber1237744-13-6
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinDMSO(10mM,gentlewarming)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforQNZ46
StructuralandmechanisticdeterminantsofanovelsitefornoncompetitiveinhibitionofGluN2D-containingNMDAreceptors.
HansenKBetal(2011)JNeurosci31(10):3650-61.PubMedID:21389220Quinazolin-4-onederivatives:AnovelclassofnoncompetitiveNR2C/Dsubunit-selectiveNMDAreceptorantagonists.
MosleyCAetal(2010)JMedChem53(15):5476-90.PubMedID:20684595
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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