你好Bio/PP 1/HB1334/25mg
市场价：
¥7020.00
美元价：
5400.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NamePP1
- ShortdescriptionPotentSrc-familytyrosinekinaseinhibitor
- BIOLOGicaldescriptionPotentSrc-familytyrosinekinaseinhibitor.SelectiveforLckandFynToverEGF-R,JAK2andZAP-70(IC50valuesare5and6nM,0.25,>50and>100µMrespectively).AlsoinhibitsKit,Bcr-Abl,c-AblandMAPkinasep38.Showsanti-cancer,antiproliferativeandapoptoticactions.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- MolecularWeight281.36
- MolecularFormulaC16H19N5
- CASNumber172889-26-8
StoringandUsingYourProduct
- Storageinstructions+4°C(desiccate)
- SolubilityoverviewsolubleinDMSO(10mM)orethanol(10mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforPP1
Discoveryofanovel,potent,andSrcfamily-selectivetyrosinekinaseinhibitor.StudyofLck-andFynT-dependentTcellactivation.
HankeJHetal(1996)JBiolChem271(2):695-701.PubMedID:8557675StructuralbasisforselectiveinhibitionofSrcfamilykinasesbyPP1.
LiuYetal(1999)ChemBiol6(9):671-8.PubMedID:10467133TheSrc-selectivekinaseinhibitorPP1alsoinhibitsKitandBcr-Abltyrosinekinases.
TattonLetal(2003)JBiolChem278(7):4847-53.PubMedID:12475982TheSrcfamilykinaseinhibitorsPP2andPP1effectivelyblockTGF-beta1-inducedcellmigrationandinvasioninbothestablishedandprimarycarcinomacells.
BartschtTetal(2012)CancerChemotherPharmacol70(2):221-30.PubMedID:22699812
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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