Hello Bio/PP 1/HB1334/10mg
市场价：
¥3510.00
美元价：
2700.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NamePP 1
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Short descriptionPotent Src-family tyrosine kinase inhibitor
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Biological descriptionPotent Src-family tyrosine kinase inhibitor. Selective for Lck and Fyn T over EGF-R, JAK2 and ZAP -70 (IC50 values are 5 and 6 nM, 0.25, >50 and > 100 µM respectively). Also inhibits Kit, Bcr-Abl, c-Abl and MAP kinase p38. Shows anti-cancer, antiproliferative and apoptotic actions.
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Biological actionInhibitor
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Purity>99%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Molecular Weight281.36
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Molecular FormulaC16H19N5
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CAS Number172889-26-8
Storing and Using Your Product
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Storage instructions+4°C (desiccate)
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Solubility overviewsoluble in DMSO (10mM) or ethanol (10mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for PP 1
Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation.
Hanke JH et al (1996) J Biol Chem 271(2) : 695-701.PubMedID: 8557675Structural basis for selective inhibition of Src family kinases by PP1.
Liu Y et al (1999) Chem Biol 6(9) : 671-8.PubMedID: 10467133The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases.
Tatton L et al (2003) J Biol Chem 278(7) : 4847-53.PubMedID: 12475982The Src family kinase inhibitors PP2 and PP1 effectively block TGF-beta1-induced cell migration and invasion in both established and primary carcinoma cells.
Bartscht T et al (2012) Cancer Chemother Pharmacol 70(2) : 221-30.PubMedID: 22699812
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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