Hello Bio/PNU 74654/HB0528/50mg
市场价：
¥7683.00
美元价：
5910.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NamePNU 74654
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Short descriptionβ-catenin inhibitor. Wnt pathway inhibitor.
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Biological descriptionβ-catenin inhibitor (Kd = 450 nM). Blocks the interaction with T cell factor (TCF). Inhibits the Wnt/β-catenin pathway.
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Biological actionInhibitor
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Purity>99%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide
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Molecular Weight320.34
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Chemical structure
![PNU 74654 [113906-27-7]](images/hellobio/201710/hb0528.png "PNU 74654 [113906-27-7]")
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Molecular FormulaC19H16N2O3
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CAS Number113906-27-7
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PubChem identifier60119583
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SMILESCC1=CC=C(O1)C=NNC(=O)C2=CC=CC=C2OC3=CC=CC=C3
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewsoluble in DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for PNU 74654
Characterization of differential gene expression in adrenocortical tumors harboring beta-catenin (CTNNB1) mutations.
Durand J et al (2011) J Clin Endocrinol Metab 96(7) : E1206-11.PubMedID: 21565795Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening.
Trosset JY et al (2006) Proteins 64(1) : 60-7.PubMedID: 16568448Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.
Wells JA et al (2007) Nature 450(7172) : 1001-9.PubMedID: 18075579
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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