Hello Bio/PKC-412/HB0521/1mg
市场价：
¥3373.50
美元价：
2595.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
-
NamePKC-412
-
Short descriptionBroad spectrum protein kinase inhibitor
-
Biological descriptionBroad spectrum protein kinase inhibitor. Inhibits PKC (isoforms α, β and γ), Syk, FLK-1, PKA, c-kit, Akt, FLT3, VEGFR1, VEGFR2, EGFR and c-src. Also selectively blocks TNF-α production. Displays antitumor, antiproliferative and pro-apoptotic properties.
-
Alternative namesCGP 41251; Midostaurin; 4'-N-benzoylstaurosporine; PKC412
-
Biological actionInhibitor
-
Purity>96%
-
Our products in actionSubmit Your Citation Now
Properties
-
Chemical nameMidostaurin; 4'-N-benzoylstaurosporine
-
Molecular Weight570.64
-
Chemical structure
![PKC-412 [120685-11-2]](images/hellobio/201710/hb0521.png "PKC-412 [120685-11-2]")
-
Molecular FormulaC35H30N4O4
-
CAS Number120685-11-2
Storing and Using Your Product
-
Solubility overviewsoluble in DMSO (15mg/ml) or MDC (10mg/ml)
-
ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for PKC-412
PKC412--a protein kinase inhibitor with a broad therapeutic potential.
Fabbro D et al (2000) Anticancer Drug Des 15(1) : 17-28.PubMedID: 10888033Effects of the kinase inhibitor CGP41251 (PKC 412) on lymphocyte activation and TNF-alpha production.
Si MS et al (2005) Int Immunopharmacol 5(7-8) : 1141-9.PubMedID: 15914319The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C.
Tenzer A et al (2001) Cancer Res 61(22) : 8203-10.PubMedID: 11719451PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts.
Nakazono-Kusaba A et al (2004) Eur J Pharmacol 497(2) : 155-60.PubMedID: 15306200
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
