Hello Bio/Picrotoxin/HB0506/5x1g-免疫在线蚂蚁淘旗下平台

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Hello Bio/Picrotoxin/HB0506/5x1g

商品编号： HB0506-1g

品牌： hellobio

市场价： ¥468.00

美元价： 360.00

产地：美国(厂家直采)

公司：

产品分类：酸碱缓冲液

公司分类： acid_base_buffer_solution

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Productoverview

Name
Picrotoxin
Shortdescription
Non-competitiveGABA_AreceptorantagoNIST
BIOLOGicaldescription
Non-competitiveGABA_Areceptorantagonist.Alsoaglycinereceptorinhibitor(IC₅₀=2.7µM).ActsasaconvulsantandCNSstimulant.Activeinvivo.
Alternativenames
PTX
Biologicalaction
Antagonist
Purity
>98%
Customercomments
GettingonwellwithDHPG&picrotoxin–theydowhatthey’resupposedto!ProfessorBrunoFrenguelli,UniversityofWarwick,UK
Ourproductsinaction
3citationsSubmitYourCitationNow

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Properties

MolecularWeight
602.59
Chemicalstructure
MolecularFormula
C₃₀H₃₄O₁₃
CASNumber
124-87-8
PubChemidentifier
518601
SMILES
CC(=C)C1C2C3C4(C(C1C(=O)O2)(CC5C4(O5)C(=O)O3)O)C.CC12C3C4C(C(C1(CC5C2(O5)C(=O)O3)O)C(=O)O4)C(C)(C)O
InChi
InChI=1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3
InChiKey
VJKUPQSHOVKBCO-UHFFFAOYSA-N
MDLnumber
MFCD00074824

Applications

Applicationnotes
TheGABA_AreceptorantagonistPicrotoxiniscommonlyusedtoreducethelevelsinhibitionbyblockingtheactionsoftheneurotransmitterGABA.PicrotoxinfromHelloBioreducesbothspontaneousinhibitorypostsynapticcurrents(IPSC)andevokedIPSCs.Itwaseffectiveatconcentrationsof10μM,withcompletereceptorblockadeat100μM.Forassayprotocol,see#Protocol1inApplicationNotesbelow

#Protocol1:Evokedandspontaneousinhibitorypostsynapticcurrents(IPSCs)
- WholecellvoltageclamprecordingswereobtainedfromlayerVneuronsofthemouseprelimbiccortexbrainslice.
- AstimulatingelectrodewasplacedinlayersII/IIIandIPSCswereevokedbyasinglesquare(150μs)pulseevery10secatastimulusintensitythatgaveareliableIPSC.
- IPSCswereevokedatarangeofneuronholdingvoltagestomeasurethereversalpotentialofthecurrenttoensureitwasGABAergic.
- Neuronswereheldat0mVandIPSCscontinuouslystimulatedandrecordedinresponseto5minapplicationsofvaryingconcentrationsofGabazineuntilcompletereceptorinhibition.
- SpontaneousIPSCswererecordedbeforeandafteradditionofGabazinebyholdingtheneuronat0mVandrecordingfor10sec.
- AllrecordingsforIPSCsweremadeinthepresenceofAMPARantagonists.

StoringandUsingYourProduct

Storageinstructions
Roomtemperature
Solubilityoverview
SolubleinDMSO(100mM)andinethanol(50mM,gentlewarming)
Important
ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforPicrotoxin

Picrotoxin-likechannelblockersofGABAAreceptors.
OlsenRW(2006)ProcNatlAcadSciUSA103(16):6081-2.
PubMedID:16606858
Mechanismsforpicrotoxinblockofalpha2homomericglycinereceptors.
WangDSetal(2006)JBiolChem281(7):3841-55.
PubMedID:16344549
Picrotoxinblockadeofinvertebrateglutamate-gatedchloridechannels:subunitdependenceandevidenceforbindingwithinthepore.
EtterAetal(1999)JNeuRochem72(1):318-26.
PubMedID:9886084

品牌介绍

Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.

公司介绍

品牌分类

拮抗剂和抑制剂抗生素激动剂和活化剂初级的染料和污渍

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