你好Bio/PHT 427/HB1251/50mg
商品编号：
HB1251-50mg
品牌：
hellobio
市场价：
¥3568.50
美元价：
2745.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NamePHT427
- ShortdescriptionAkt/PDPK1inhibitor
- BIOLOGicaldescriptionAkt(PKB)andphosphatidylinositol3-kinase(PDPK1)inhibitor(Kivaluesare2.7and5.2µMrespectively).Bindsatthepleckstrinhomology(PH)domainofAKTandPDPK1.Showsanti-tumorandapoptoticactions.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-Dodecyl-N-1,3,4-thiADIazol-2-yl-benzenesulfonamide
- MolecularWeight409.61
- Chemicalstructure
![PHT 427 [1191951-57-1]](images/hellobio/201710/hb1251.png "PHT 427 [1191951-57-1]")
- MolecularFormulaC20H31N3O2S2
- CASNumber1191951-57-1
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforPHT427
Invitroandinvivoactivityofnovelsmall-moleculeinhibitorstargetingthepleckstrinhomologydomainofproteinkinaseB/AKT.
MosesSAetal(2009)CancerRes69(12):5073-81.PubMedID:19491272MolecularpharmacologyandantitumoractivityofPHT-427,anovelAkt/phosphatidylinositide-dependentproteinkinase1pleckstrinhomologydomaininhibitor.
MeuilletEJetal(2010)MolCancerTher9(3):706-17.PubMedID:20197390
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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