Hello Bio/Philanthotoxin-7,4/HB0499/
市场价：
¥1170.00
美元价：
900.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NamePhilanthotoxin-7,4
- ShortdescriptionAMPAreceptorantagoNIST
- BIOLOGicaldescriptionAMPAreceptorantagonist.Non-selectiveinhibitorofhomomericGluA1andGluA3subunit-containingreceptorsandheteromericreceptorGluA1/2subunits(IC50=22µM).
- BiologicalactionAntagonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamidedihydrochloride
- MolecularWeight507.54
- Chemicalstructure
![Philanthotoxin-7,4 [1227301-51-0]](images/hellobio/201710/hb0499.png "Philanthotoxin-7,4 [1227301-51-0]")
- MolecularFormulaC24H42N4O3.2HCl
- CASNumber1227301-51-0
- PubChemidentifier46213501
- SMILESCl.Cl.Oc1ccc(C[C@H](NC(=O)CCC)C(=O)NCCCCCCCNCCCCN)cc1
StoringandUsingYourProduct
- Storageinstructionsroomtemperature(desiccate)
- Solubilityoverviewsolubleinwater(100mM)orDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforPhilanthotoxin-7,4
Asubtype-selective,use-dependentinhibitorofnativeAMPAreceptors.
NilsenAetal(2007)JAmChemSoc129(16):4902-3.PubMedID:17391037EvaluationofPhTX-74assubtype-selectiveinhibitorofGluA2-containingAMPAreceptors.
PoulsenMHetal(2014)MolPharmacol85(2):261-8.PubMedID:24220009Solid-phasesynthesisofpolyaminetoxinanalogues:potentandselectiveantagonistsofCa2+-permeableAMPAreceptors.
KromannHetal(2002)JMedChem45(26):5745-54.PubMedID:12477358
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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