Hello Bio/Philanthotoxin-7,4/HB0499/10mg
商品编号：
HB0499-10mg
品牌：
hellobio
市场价：
¥1872.00
美元价：
1440.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NamePhilanthotoxin-7,4
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Short descriptionAMPA receptor antagonist
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Biological descriptionAMPA receptor antagonist. Non-selective inhibitor of homomeric GluA1 and GluA3 subunit-containing receptors and heteromeric receptor GluA1/2 subunits (IC50 = 22 µM).
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Biological actionAntagonist
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name(S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamide dihydrochloride
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Molecular Weight507.54
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Chemical structure
![Philanthotoxin-7,4 [1227301-51-0]](images/hellobio/201710/hb0499.png "Philanthotoxin-7,4 [1227301-51-0]")
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Molecular FormulaC24H42N4O3.2HCl
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CAS Number1227301-51-0
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PubChem identifier46213501
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SMILESCl.Cl.Oc1ccc(C[C@H](NC(=O)CCC)C(=O)NCCCCCCCNCCCCN)cc1
Storing and Using Your Product
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Storage instructionsroom temperature (desiccate)
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Solubility overviewsoluble in water (100mM) or DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Philanthotoxin-7,4
A subtype-selective, use-dependent inhibitor of native AMPA receptors.
Nilsen A et al (2007) J Am Chem Soc 129(16) : 4902-3.PubMedID: 17391037Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors.
Poulsen MH et al (2014) Mol Pharmacol 85(2) : 261-8.PubMedID: 24220009Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors.
Kromann H et al (2002) J Med Chem 45(26) : 5745-54.PubMedID: 12477358
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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