Hello Bio/PF 3716556/HB1123/50mg
商品编号：
HB1123-50mg
品牌：
hellobio
市场价：
¥5947.50
美元价：
4575.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NamePF3716556
- ShortdescriptionPotent,selectiveacidpumpantagoNIST
- BIOLOGicaldescriptionPotentandselectiveacidpumpantagonist(pIC50valuesare6.03,6.04and6.01forPorcine,CanineandHumanrecombinantionleakyassayrespectively).CompetitivelyinhibitsH+,K+-ATPasebutexhibitsnoactivityagainstNa+,K+-ATPase.Displaysgreaterpotencyinacidicconditions.Alsoinhibitsgastricacidsecretionindogs.
- BiologicalactionAntagonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname8-[[(4R)-3,4-Dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl-imidazo[1,2-a]pyridine-6-carboxamide
- MolecularWeight394.47
- Chemicalstructure
![PF 3716556 [928774-43-0]](images/hellobio/201710/hb1123.png "PF 3716556 [928774-43-0]")
- MolecularFormulaC22H26N4O3
- CASNumber928774-43-0
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforPF3716556
N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide(PF-03716556),anovel,potent,andselectiveacidpumpantagonistforthetreatmentofgastroesophagealrefluxdisease.
MoriHetal(2009)JPharmacolExpTher328(2):671-9.PubMedID:18981288
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
