Hello Bio/PF 03814735/HB1441/50mg
商品编号：
HB1441-50mg
品牌：
hellobio
市场价：
¥7234.50
美元价：
5565.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NamePF 03814735
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Short descriptionPotent Aurora kinase inhibitor
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Biological descriptionPotent Aurora kinase inhibitor. Reversibly inhibits Aurora B and -A (IC50 values are 0.8 and 5 nM respectively). Shows antiproliferative and anti-cancer actions.
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Biological actionInhibitor
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical nameN-[2-[(1S,4R)-6-[[4-(Cyclobutylamin o)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3, 4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]- acetamide
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Molecular Weight474.48
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Chemical structure
![PF 03814735 [942487-16-3]](images/hellobio/201710/hb1441.png "PF 03814735 [942487-16-3]")
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Molecular FormulaC23H25F3N6O2
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CAS Number942487-16-3
Storing and Using Your Product
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Storage instructions-20°C
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Solubility overviewsoluble in DMSO (100mM) or ethanol (20mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for PF 03814735
PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy.
Jani JP et al (2010) Mol Cancer Ther 9(4) : 883-94.PubMedID: 20354118An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735.
Hook KE et al (2012) Mol Cancer Ther 11(3) : 710-9.PubMedID: 22222631
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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