Hello Bio/Penitrem A/HB1057/1mg
商品编号：
HB1057-1mg
品牌：
hellobio
市场价：
¥1111.50
美元价：
855.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NamePenitremA
- ShortdescriptionPotent,selectiveKCa1.1channelblocker
- BIOLOGicaldescriptionPotentandselectiveKCa1.1channelblocker(IC50valuesare6.4and64.4nMforα-subunitandβ1subunitsrespectively).DisplayslittleornoactivityatCaCC,Kv1.5andKATPchannels.NeurotoxinproducedbyPenicilliumgenus.Displaysenhancingsmoothmusclecontractingandtremorgenicproperties.
- BiologicalactionBlocker
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4",4"a]-1-benzopyrano[5",6":6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol
- MolecularWeight634.2
- Chemicalstructure
![Penitrem A [12627-35-9]](images/hellobio/201710/hb1057.png "Penitrem A [12627-35-9]")
- MolecularFormulaC37H44ClNO6
- CASNumber12627-35-9
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(10mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforPenitremA
PenitremAasatoolforunderstandingtheroleoflargeconductanceCa(2+)/voltage-sensitiveK(+)channelsinvascularfunction.
AsanoSetal(2012)JPharmacolExpTher342(2):453-60.PubMedID:22580348NeurotoxicityofPenicilliumcrustosumsecondarymetabolites:tremorgenicactivityoforallyadmiNISTeredpenitremAandthomitremAandEinmice.
Moldes-AnayaAetal(2012)Toxicon60(8):1428-35.PubMedID:23085423InvitroandinvivohepaticmetabolismofthefungalneurotoxinpenitremA.
Moldes-AnayaAetal(2009)DrugChemToxicol32(1):26-37.PubMedID:19514936
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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