Hello Bio/PEAQX (NVP-AAM 077)/HB2841/
市场价：
¥838.50
美元价：
645.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NamePEAQX (NVP-AAM 077)
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Short descriptionPotent, competitive NMDA receptor antagonist
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Biological description
Potent and competitive NMDA receptor antagonist. Binds at the glutamate site.
Shows some selectivity (~7-10-fold) for GluN1/2A (NR1/2A) over GluN1/2B (NR1/2B) subunit containing receptors (IC50 values are 31 and 215 nM at GluN1/2A and GluN1/2B respectively).
Shows anticonvulsant activity. Active in vivo.
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Alternative namesNVP-AAM 007
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Biological actionAntagonist
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Purity>98%
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Our products in action1 citation Submit Your Citation Now
Images
Properties
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Chemical name[[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium salt
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Molecular Weight542.14
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Chemical structure
![PEAQX [459836-30-7]](images/hellobio/201710/hb2841.png "PEAQX [459836-30-7]")
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Molecular FormulaC17H13BrN3Na4O5P
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CAS Number459836-30-7
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PubChem identifier101043065
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SMILESCC(C1=CC=C(C=C1)Br)NC(C2=C3C(=CC=C2)N=C(C(=N3)[O-])[O-])P(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+]
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InChiInChI=1S/C17H17BrN3O5P.4Na/c1-9(10-5-7-11(18)8-6-10)19-17(27(24,25)26)12-3-2-4-13-14(12)21-16(23)15(22)20-13;;;;/h4-9,17,19H,1H3,(H,20,22)(H,21,23)(H2,24,25,26);;;;/q;4*+1/p-4
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InChiKeyQBVOZIDKUFSQIL-UHFFFAOYSA-J
Storing and Using Your Product
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Storage instructions-20°C
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Solubility overviewSoluble in water (10mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for PEAQX (NVP-AAM 077)
5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition.
Auberson et al (2002) Bioorg Med Chem Lett 12(7) : 1099-102.PubMedID: 11909726Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B NMDA receptors: Implications for studies of sy
Frizelle et al (2006) Mol Pharmacol. 70(3) : 1022-32PubMedID: 16778008The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats.
Morales and Spear (2014) Psychopharmacology (Berl). 231(8) : 1797-807PubMedID: 24043344
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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