Hello Bio/PD 98059/HB2244/50mg
商品编号：
HB2244-50mg
品牌：
hellobio
市场价：
¥4192.50
美元价：
3225.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NamePD 98059
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Short descriptionSelective MEK1/MAP2K inhibitor. Enhances ESC self-renewal.
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Biological descriptionSelective MEK1/MAP2K inhibitor (IC50 values are 2 and 50 µM at MEK1 and MEK2 respectively). Binds to inactivated MEK to prevent its phosphorylation by MEK kinase or c-Raf. Inhibits cell growth and proliferation and induces modest apoptosis. Also enhances embryonic stem cell self-renewal. Active in vivo .
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Biological actionInhibitor
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Purity>98%
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Our products in action1 citation Submit Your Citation Now
Images
Properties
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Chemical name2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
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Molecular Weight267.28
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Chemical structure
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Molecular FormulaC16H13NO3
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CAS Number167869-21-8
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PubChem identifier4713
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SMILESCOC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2
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InChiInChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h4-9H,17H2,1H3
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InChiKeyQFWCYNPOPKQOKV-UHFFFAOYSA-N
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MDL numberMFCD00671789
Storing and Using Your Product
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Storage instructionsRoom temperature
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Solubility overviewSoluble in DMSO (25mM) and in ethanol (5mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for PD 98059
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo.
Alessi DR et al (1995) J Biol Chem 270(46) : 27489-94.PubMedID: 7499206A synthetic inhibitor of the mitogen-activated protein kinase cascade.
Dudley DT et al (1995) Proc Natl Acad Sci U S A 92(17) : 7686-9.PubMedID: 7644477U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells.
Hotokezaka H et al (2002) J Biol Chem 277(49) : 47366-72.PubMedID: 12237315Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor.
Pang L et al (1995) J Biol Chem 270(23) : 13585-8.PubMedID: 7775407Pre-LTP requires extracellular signal-regulated kinase in the ACC.
Yamanaka et al (2016) Mol Pain 12 : 1-12PubMedID: 27178245
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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